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KMID : 1034320180090020118
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Sleep Medicine Research
2018 Volume.9 No. 2 p.118 ~ p.123
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Clinical Characteristics and Efficacy of Iron Treatment for Restless Legs Syndrome Patients with Very Low Ferritin Levels
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Kim Tae-Joon
Jun Jin-Sun
Kim Keun-Tae
Yang Tae-Won
Park Byeong-Su
Lim Jung-Ah
Byun Jung-Ick
Sunwoo Jun-Sang
Shin Jung-Won
Jung Ki-Young
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Abstract
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Restless legs syndrome (RLS) is associated with dopaminergic dysfunction, and iron deficiency, manifesting as low ferritin. However, ferritin levels do not correlate well with demographic data. Based on the hypothesis that very low ferritin can accurately reflect clinical information, we herein described characteristics and treatment efficacy of RLS patients with ferritin levels under 15 ng/mL. We retrospectively reviewed 196 patients and collected clinical data. Twenty-one patients had ferritin levels under 15 ng/mL and were compared with those having ferritin levels over 15 ng/mL. The patients with very low ferritin levels were predominantly female, had earlier onset of symptoms, and showed a superior response to iron therapy. In conclusion, RLS patients with ferritin levels under 15 ng/mL showed distinct demographic features and treatment efficacy. Further studies on more patients with long-term follow-up are warranted to support this observation.
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KEYWORD
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Restless legs syndrome, Ferritin, Iron
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